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Drosha versus ADAR: wrangling over pri-miRNA

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Processing of a mammalian hematopoietic microRNA precursor is suppressed when it is edited by ADARs. The edited pri-miRNA can subsequently be degraded by Tudor-SN.

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Figure 1: The consequences of editing of pri–miR-142 by the nuclear editing enzymes, ADAR1p110 or ADAR2.

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O'Connell, M., Keegan, L. Drosha versus ADAR: wrangling over pri-miRNA. Nat Struct Mol Biol 13, 3–4 (2006). https://doi.org/10.1038/nsmb0106-3

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