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Navigating the ClpB channel to solution

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New work places the Hsp70/DnaK system in an opening role in protein disaggregation, facilitating the extraction of individual polypeptides from the aggregate surface to the axial channel of Hsp104/ClpB. It also reinforces a long-standing belief that reactivation rather than simple clearance of aggregated protein is necessary for cell stress tolerance.

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Figure 1: The architecture of the ClpB hexamer.
Figure 2: Modes of Hsp104/ClpB-mediated disaggregation.

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Acknowledgements

We thank A. Cashikar and G. Kramer for comments on the manuscript.

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Authors and Affiliations

  1. Whitehead Institute of Biomedical Research, 9 Cambridge Center, Cambridge, 02142, Massachusetts, USA

    James Shorter & Susan Lindquist

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  1. James Shorter
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  2. Susan Lindquist
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Shorter, J., Lindquist, S. Navigating the ClpB channel to solution. Nat Struct Mol Biol 12, 4–6 (2005). https://doi.org/10.1038/nsmb0105-4

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