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One flexible loop in OST lassos both substrates

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The crystal structure of an oligosaccharyltransferase in complex with a sugar donor and an acceptor peptide provides insight into the mechanism of protein glycosylation and reveals how lipid-linked oligosaccharides are positioned in the enzyme active site.

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Figure 1: EL5 clamps both substrates into the OST active site.

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Authors and Affiliations

  1. the Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

    Shiteshu Shrimal, Natalia A Cherepanova & Reid Gilmore

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  1. Shiteshu Shrimal
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  2. Natalia A Cherepanova
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  3. Reid Gilmore
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Correspondence to Reid Gilmore.

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The authors declare no competing financial interests.

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Shrimal, S., Cherepanova, N. & Gilmore, R. One flexible loop in OST lassos both substrates. Nat Struct Mol Biol 24, 1009–1010 (2017). https://doi.org/10.1038/nsmb.3508

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