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Oocyte-derived histone H3 lysine 27 methylation controls gene expression in the early embryo

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The monoallelic expression of many imprinted genes in mammals depends on DNA methylation marks that originate from the germ cells. Recent studies in mice and fruit flies evoke a novel, transient mode of genomic imprinting in which oocyte-acquired histone H3 Lys27 trimethylation (H3K27me3) marks are transmitted to the zygote and modulate the allele specificity and timing of gene expression in the early embryo.

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Figure 1: Chromosomal regions acquire different epigenetic states in mouse oocytes.
Figure 2: Oocyte-acquired imprints induce different chromatin organizations in the mouse embryo.

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Authors and Affiliations

  1. the Institute of Molecular Genetics of Montpellier (IGMM), CNRS and University of Montpellier, Montpellier, France

    Rakesh Pathak & Robert Feil

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  1. Rakesh Pathak
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  2. Robert Feil
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Correspondence to Robert Feil.

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Pathak, R., Feil, R. Oocyte-derived histone H3 lysine 27 methylation controls gene expression in the early embryo. Nat Struct Mol Biol 24, 685–686 (2017). https://doi.org/10.1038/nsmb.3456

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