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mRNA decapping in 3D

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The degradation of mRNAs involves removal of the 5′ protective cap via a decapping-enzyme complex, in a largely irreversible process that commits the transcript for destruction. Understanding how the decapping reaction is catalyzed and regulated are major goals in the field. New data suggest how the chemistry of decapping is controlled and orchestrated within the cell.

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Figure 1: Distinct states of the decapping-enzyme complex Dcp2–Dcp1 that may be on pathway to cap hydrolysis.

Marina Corral Spence/Nature Publishing Group

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Acknowledgements

I thank J. Gross and E. Izaurralde for helpful discussions. Work was supported by a grant from the NIGMS (GM080465).

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  1. Jeff Coller is at the Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, Ohio USA.,

    Jeff Coller

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  1. Jeff Coller
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Correspondence to Jeff Coller.

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Coller, J. mRNA decapping in 3D. Nat Struct Mol Biol 23, 954–956 (2016). https://doi.org/10.1038/nsmb.3315

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