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Noncoding RNA joins Ku and DNA-PKcs for DNA-break resistance in breast cancer

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The noncoding RNA LINP1 acts as a scaffold that links Ku and DNA-PKcs and enables efficient DNA double-strand-break repair through nonhomologous end joining (NHEJ), thereby enhancing the resistance of triple-negative breast cancer cells to radiation and chemotherapies.

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Figure 1: Regulation of NHEJ by LINP1 in TNBC.

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Authors and Affiliations

  1. Susan P. Lees-Miller and Tara L. Beattie are at the Department of Biochemistry and Molecular Biology, Robson DNA Science Centre, Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada.,

    Susan P Lees-Miller & Tara L Beattie

  2. John A. Tainer is at the Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.,

    John A Tainer

Authors
  1. Susan P Lees-Miller
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  2. Tara L Beattie
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  3. John A Tainer
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Correspondence to Susan P Lees-Miller.

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Lees-Miller, S., Beattie, T. & Tainer, J. Noncoding RNA joins Ku and DNA-PKcs for DNA-break resistance in breast cancer. Nat Struct Mol Biol 23, 509–510 (2016). https://doi.org/10.1038/nsmb.3240

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