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Src defines a new pool of EGFR substrates

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The mechanisms guiding the substrate specificity of kinases are still poorly understood. Two recent reports provide further insights into how the epidermal growth factor receptor (EGFR) tyrosine kinase recognizes targets by identifying a new consensus motif that requires a Src-mediated priming phosphorylation.

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Figure 1: Structural basis for the binding of primed YY motifs to the EGFR kinase.
Figure 2: Distinct mechanisms of substrate recognition by the EGFR kinase modulate EGFR signaling output.

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Authors and Affiliations

  1. Nicole Michael and Natalia Jura are at the Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA.,

    Nicole Michael & Natalia Jura

  2. Natalia Jura is also at the Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California, USA.,

    Natalia Jura

Authors
  1. Nicole Michael
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  2. Natalia Jura
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Correspondence to Natalia Jura.

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The authors declare no competing financial interests.

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Michael, N., Jura, N. Src defines a new pool of EGFR substrates. Nat Struct Mol Biol 22, 945–947 (2015). https://doi.org/10.1038/nsmb.3137

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