Skip to main content
SpringerLink
Log in

SEC-uring membrane fusion: a sneak peek at SNARE-complex assembly driven by Sec1–Munc18 proteins

  • News & Views
  • Published:

From Nature Structural & Molecular Biology

View current issue Submit your manuscript

How is cellular cargo delivered at the right time and the right place, in response to the right signal? A key new piece in this fascinating biological puzzle has just been revealed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Schematic representation of membrane fusion mediated by SNARE proteins.
Figure 2: SM proteins promote membrane fusion.

References

  1. Ray, K. J. Biosci. 39, 3–12 (2014).

    Article  CAS  PubMed  Google Scholar 

  2. Baker, R.W. et al. Science 349, 1111–1114 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Sutton, R.B., Fasshauer, D., Jahn, R. & Brunger, A.T. Nature 395, 347–353 (1998).

    CAS  PubMed  Google Scholar 

  4. Misura, K.M., Scheller, R.H. & Weis, W.I. Nature 404, 355–362 (2000).

    Article  CAS  PubMed  Google Scholar 

  5. Burkhardt, P., Hattendorf, D.A., Weis, W.I. & Fasshauer, D. EMBO J. 27, 923–933 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Burkhardt, P. et al. Proc. Natl. Acad. Sci. USA 108, 15264–15269 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Hu, S.H. et al. Proc. Natl. Acad. Sci. USA 108, 1040–1045 (2011).

    Article  CAS  PubMed  Google Scholar 

  8. Parisotto, D. et al. J. Biol. Chem. 289, 9639–9650 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Martin, S. et al. J. Cell Sci. 126, 2353–2360 (2013).

    Article  CAS  PubMed  Google Scholar 

  10. Han, G.A., Bin, N.R., Kang, S.Y., Han, L. & Sugita, S. J. Cell Sci. 126, 2361–2371 (2013).

    Article  CAS  PubMed  Google Scholar 

  11. Boyd, A. et al. Genetics 180, 165–178 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Xu, Y., Su, L. & Rizo, J. Biochemistry 49, 1568–1576 (2010).

    Article  CAS  PubMed  Google Scholar 

  13. Li, Y., Schmitt, H.D., Gallwitz, D. & Peng, R.W. FEBS Lett. 581, 5698–5702 (2007).

    Article  CAS  PubMed  Google Scholar 

  14. Yang, X. et al. Nat. Struct. Mol. Biol. 22, 547–554 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Hu, S.H., Latham, C.F., Gee, C.L., James, D.E. & Martin, J.L. Proc. Natl. Acad. Sci. USA 104, 8773–8778 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Brett M. Collins and Jennifer L. Martin are at the Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.,

    Brett M Collins & Jennifer L Martin

Authors
  1. Brett M Collins
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jennifer L Martin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jennifer L Martin.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Collins, B., Martin, J. SEC-uring membrane fusion: a sneak peek at SNARE-complex assembly driven by Sec1–Munc18 proteins. Nat Struct Mol Biol 22, 756–758 (2015). https://doi.org/10.1038/nsmb.3094

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb.3094

  • Springer Nature America, Inc.

Search

Navigation