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Structures of human DNA polymerases ν and θ expose their end game

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Although the two B-family human DNA polymerases, pol δ and pol ε, are responsible for the bulk of nuclear genome replication, at least 14 additional polymerases have roles in nuclear DNA repair and replication. In this issue, newly reported crystal structures of two specialized A-family polymerases, pol ν and pol θ, expose these enzymes' strategies for handling aberrant DNA ends.

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Figure 1: Structural organization of pol ν and pol θ bound to DNA.
Figure 2: Pol ν fidelity for dTTP misinsertion opposite template dG.

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Authors and Affiliations

  1. William A. Beard and Samuel H. Wilson are at the Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA.,

    William A Beard & Samuel H Wilson

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  1. William A Beard
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  2. Samuel H Wilson
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Correspondence to Samuel H Wilson.

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Beard, W., Wilson, S. Structures of human DNA polymerases ν and θ expose their end game. Nat Struct Mol Biol 22, 273–275 (2015). https://doi.org/10.1038/nsmb.3006

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