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Optimizing membrane-protein biogenesis through nonoptimal-codon usage

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Two studies provide insights into the distinct strategies used by prokaryotes and eukaryotes to pause translation in order to facilitate cotranslational targeting of membrane proteins to the translocon.

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Figure 1: Mechanisms of translational pausing during membrane-protein synthesis rely on mRNA-encoded signals in both prokaryotes and eukaryotes.

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Acknowledgements

We thank M. Hegde, B. Santhanam, T. Flock, N.S. Latysheva, J.T. Harbrecht, G. Chalancon and M. Torrent for their feedback. This work was supported by the UK Medical Research Council (MC_U105185859; A.S.M. and M.M.B.) and The Lister Institute of Preventive Medicine (M.M.B.). M.M.B. is supported as a Lister Institute Research Prize Fellow.

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  1. Alexey S. Morgunov and M. Madan Babu are at the Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.,

    Alexey S Morgunov & M Madan Babu

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  1. Alexey S Morgunov
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  2. M Madan Babu
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Correspondence to Alexey S Morgunov or M Madan Babu.

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Morgunov, A., Babu, M. Optimizing membrane-protein biogenesis through nonoptimal-codon usage. Nat Struct Mol Biol 21, 1023–1025 (2014). https://doi.org/10.1038/nsmb.2926

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