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Dynamic activation of apoptosis: conformational ensembles of cIAP1 are linked to a spring-loaded mechanism

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cIAP1 undergoes a dramatic conformational change during activation that is now shown to be due to the dynamic and metastable nature of the closed form of the enzyme. The discovery of such a striking mechanism for functional control was enabled by state-of-the-art enzymological and biophysical methods.

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Figure 1: Structure of cIAP1.

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Authors and Affiliations

  1. Michelle L. Gill & R. Andrew Byrd are at the Structural Biophysics Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA.,

    Michelle L Gill & R Andrew Byrd

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  1. Michelle L Gill
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  2. R Andrew Byrd
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Correspondence to R Andrew Byrd.

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The authors declare no competing financial interests.

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Gill, M., Byrd, R. Dynamic activation of apoptosis: conformational ensembles of cIAP1 are linked to a spring-loaded mechanism. Nat Struct Mol Biol 21, 1022–1023 (2014). https://doi.org/10.1038/nsmb.2925

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