Skip to main content
SpringerLink
Log in

It takes two to tangle: Prp24 and spliceosome assembly

  • News & Views
  • Published:

From Nature Structural & Molecular Biology

View current issue Submit your manuscript

X-ray structural analysis of spliceosomal U6 small nuclear RNA bound to Prp24 reveals a complex interlocked RNA–protein assembly and suggests models for key steps in spliceosome assembly and recycling.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Model of the U6 snRNP core complex.

Debbie Maizels/Nature Publishing Group

Accession codes

Accessions

Protein Data Bank

References

  1. Fica, S.M., Mefford, M.A., Piccirilli, J.A. & Staley, J.P. Nat. Struct. Mol. Biol. 21, 464–471 (2014).

    Article  CAS  Google Scholar 

  2. Raghunathan, P.L. & Guthrie, C. Science 279, 857–860 (1998).

    Article  CAS  Google Scholar 

  3. Montemayor, E.J. et al. Nat. Struct. Mol. Biol. 21, 544–551 (2014).

    Article  CAS  Google Scholar 

  4. Fica, S.M. et al. Nature 503, 229–234 (2013).

    Article  CAS  Google Scholar 

  5. Kenan, D.J., Query, C.C. & Keene, J.D. Trends Biochem. Sci. 16, 214–220 (1991).

    Article  CAS  Google Scholar 

  6. Oubridge, C., Ito, N., Evans, P.R., Teo, C.H. & Nagai, K. Nature 372, 432–438 (1994).

    Article  CAS  Google Scholar 

  7. Galej, W.P., Oubridge, C., Newman, A.J. & Nagai, K. Nature 493, 638–643 (2013).

    Article  CAS  Google Scholar 

  8. Martin-Tumasz, S., Reiter, N.J., Brow, D.A. & Butcher, S.E. RNA 16, 792–804 (2010).

    Article  CAS  Google Scholar 

  9. Daubner, G.M., Cléry, A. & Allain, F.H. Curr. Opin. Struct. Biol. 23, 100–108 (2013).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Daniel A. Pomeranz Krummel is at the Department of Biochemistry, Brandeis University, Waltham, Massachusetts, USA.,

    Daniel A Pomeranz Krummel

  2. Andrew M. MacMillan is at the Department of Biochemistry, University of Alberta, Edmonton, Canada.,

    Andrew M MacMillan

Authors
  1. Daniel A Pomeranz Krummel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Andrew M MacMillan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Daniel A Pomeranz Krummel or Andrew M MacMillan.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Pomeranz Krummel, D., MacMillan, A. It takes two to tangle: Prp24 and spliceosome assembly. Nat Struct Mol Biol 21, 503–504 (2014). https://doi.org/10.1038/nsmb.2838

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb.2838

  • Springer Nature America, Inc.

Search

Navigation