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Gathering around Firre

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Long noncoding RNAs (lncRNAs) have divergent roles in the nuclei of higher eukaryotes, including chromatin modification and regulation of nuclear bodies. A new study adds a new lncRNA function to the current list: serving as a platform for trans-chromosomal associations. At least three gene loci located on different chromosomes are brought together around the transcription site of a lncRNA termed functional intergenic repeating RNA element (Firre).

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Figure 1: Structure of Firre and the proposed mechanism of chromosomal localization.
Figure 2: Trans-chromosomal assembly of multiple gene loci mediated by Firre.

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Authors and Affiliations

  1. Shinichi Nakagawa is at the RNA Biology Laboratory, RIKEN, Wako, Japan.,

    Shinichi Nakagawa

  2. Tatsuya Hirano is at the Chromosome Dynamics Laboratory, RIKEN, Wako, Japan.,

    Tatsuya Hirano

Authors
  1. Shinichi Nakagawa
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  2. Tatsuya Hirano
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Correspondence to Shinichi Nakagawa.

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The authors declare no competing financial interests.

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Nakagawa, S., Hirano, T. Gathering around Firre. Nat Struct Mol Biol 21, 207–208 (2014). https://doi.org/10.1038/nsmb.2782

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