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Chromatin remodeling: a collaborative effort

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Enzymes that alter nucleosome structure or position are at the very center of gene and genome regulation, and understanding how, and to what extent, these diverse activities collaborate and control each other to shape the genome for dynamic regulation is a major challenge. A new study provides an important step in this direction by illustrating the cooperative nature of ATP-dependent chromatin-remodeling systems in mammalian cells.

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Figure 1: Features of Brg1-, Chd4- and Snf2h-containing chromatin-remodeling complexes from mammalian cells.

Katie Vicari

Figure 2: Several scenarios illustrating how two distinct chromatin-remodeling complexes (complex 1 and complex 2) may regulate chromatin accessibility over the same site.

Katie Vicari

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Authors and Affiliations

  1. Patrick D. Varga-Weisz is at the Nuclear Dynamics Programme, Babraham Institute, Cambridge, UK.,

    Patrick D Varga-Weisz

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  1. Patrick D Varga-Weisz
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Correspondence to Patrick D Varga-Weisz.

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Varga-Weisz, P. Chromatin remodeling: a collaborative effort. Nat Struct Mol Biol 21, 14–16 (2014). https://doi.org/10.1038/nsmb.2748

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