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From pseudo-ceRNAs to circ-ceRNAs: a tale of cross-talk and competition

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RNA is believed to have been the first reservoir of genetic information, but despite its ancient history, RNA continues to fascinate and is only now beginning to be understood in its entire variety and communication modality. New discoveries include the pseudogene RNA network regulating PTEN transcription and translation and the identification of circular RNAs as a new class of competing endogenous RNA molecules that sequester microRNAs to suppress their function.

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Figure 1: New RNA species counteract miRNA function.
Figure 2: circRNAs enhance ceRNAs cross-talk.

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Acknowledgements

We thank F. Bersani and Y. Tay for helpful discussions and comments and T. Garvey for critical editing of the manuscript. Our work is supported by the US National Institutes of Health and National Cancer Institute. R.T. is supported by a Marie Curie International Outgoing Fellowship for Career Development (project DECODER 273518). C.L. is supported by a Fondazione Marche and Italian Scientists and Scholars in North America Foundation postdoctoral fellowship.

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Authors and Affiliations

  1. Departments of Medicine and Pathology, Riccardo Taulli, Cristian Loretelli and Pier Paolo Pandolfi are at the Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.,

    Riccardo Taulli, Cristian Loretelli & Pier Paolo Pandolfi

  2. Riccardo Taulli is also at the Department of Oncology, University of Turin School of Medicine, Turin, Italy.,

    Riccardo Taulli

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  1. Riccardo Taulli
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  2. Cristian Loretelli
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  3. Pier Paolo Pandolfi
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Correspondence to Pier Paolo Pandolfi.

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Taulli, R., Loretelli, C. & Pandolfi, P. From pseudo-ceRNAs to circ-ceRNAs: a tale of cross-talk and competition. Nat Struct Mol Biol 20, 541–543 (2013). https://doi.org/10.1038/nsmb.2580

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