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Monomeric actin required for INO80 remodeling

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Nuclear actin is a subunit of several chromatin-remodeling complexes, and the efficient binding of INO80 to extranucleosomal DNA is now shown to require actin. The form of actin present in the INO80 complex is monomeric and cannot associate with actin filaments.

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Figure 1: The universal role of actin in ATP-dependent chromatin remodeling.
Figure 2: Analysis of the structural and functional role of actin in INO80.
Figure 3: Model of the Arp4–actin structure.

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  1. Blaine Bartholomew is at the Southern Illinois University School of Medicine, Carbondale, Illinois, USA.,

    Blaine Bartholomew

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  1. Blaine Bartholomew
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Correspondence to Blaine Bartholomew.

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Bartholomew, B. Monomeric actin required for INO80 remodeling. Nat Struct Mol Biol 20, 405–407 (2013). https://doi.org/10.1038/nsmb.2553

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