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Tyrosyl DNA phosphodiesterase 2, an enzyme fit for purpose

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Three structures were recently reported for tyrosyl DNA phosphodiesterase 2 (Tdp2), a protein that protects the metazoan genome from shredding following abortive topoisomerase activity. The physiological significance of these findings is discussed here.

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Figure 1: Model for Tdp2-dependent repair of Top2-induced DNA DSBs.

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Authors and Affiliations

  1. Keith W. Caldecott is at the Genome Damage and Stability Centre, University of Sussex, Brighton, UK.,

    Keith W. Caldecott

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  1. Keith W. Caldecott
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Correspondence to Keith W. Caldecott.

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Caldecott, K. Tyrosyl DNA phosphodiesterase 2, an enzyme fit for purpose. Nat Struct Mol Biol 19, 1212–1213 (2012). https://doi.org/10.1038/nsmb.2455

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