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The spindle-assembly checkpoint and the beauty of self-destruction

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An Erratum to this article was published on 05 February 2013

This article has been updated

Mitotic exit follows shortly after microtubule attachment of the last unattached kinetochore. Two new studies illustrate the molecular basis of this dependency.

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Figure 1: A primer of mitosis.
Figure 2: Systems-level self-destruction.

Change history

  • 20 December 2012

    In the version of this article initially published, in the lower part of Figure 2, the upper arrow connecting Cdc20 to the APC/C to form APC/CCdc20 pointed in the wrong direction. The error has been corrected in the HTML and PDF versions of the article.

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Authors and Affiliations

  1. Andrea Musacchio is at the Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany, and the Centre for Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany.,

    Andrea Musacchio

  2. Andrea Ciliberto is at the Institute for Molecular Oncology of the Italian Foundation for Cancer Research, Milan, Italy.,

    Andrea Ciliberto

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  1. Andrea Musacchio
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  2. Andrea Ciliberto
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Correspondence to Andrea Musacchio or Andrea Ciliberto.

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Musacchio, A., Ciliberto, A. The spindle-assembly checkpoint and the beauty of self-destruction. Nat Struct Mol Biol 19, 1059–1061 (2012). https://doi.org/10.1038/nsmb.2429

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