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PARP pairs up to PARsylate

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New structural analyses suggest two different models for poly(ADP-ribose) polymerase 1 (PARP1) activation by single- and double-strand DNA breaks, providing evidence for PARP1 activation in cis and in trans.

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Figure 1: The molecular architecture of human PARP1.
Figure 2: Mechanisms of PARP1 activation.

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Authors and Affiliations

  1. Nicolas Coquelle and J.N. Mark Glover are at the Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.,

    Nicolas Coquelle & J N Mark Glover

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  1. Nicolas Coquelle
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  2. J N Mark Glover
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Correspondence to J N Mark Glover.

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The authors declare no competing financial interests.

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Coquelle, N., Glover, J. PARP pairs up to PARsylate. Nat Struct Mol Biol 19, 660–661 (2012). https://doi.org/10.1038/nsmb.2306

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