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Cbl exposes its RING finger

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The Cbl family of RING finger ubiquitin ligases regulates signaling in many systems. Two new studies provide a structural basis for how phosphorylation of a specific tyrosine in the Cbl proteins enhances their ubiquitin ligase activity, giving insight into how ubiquitination by Cbl proteins is restricted to specific substrates.

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Figure 1: The Cbl proteins.
Figure 2: Model of Cbl function.

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Authors and Affiliations

  1. Stephen C. Kales, Philip E. Ryan and Stanley Lipkowitz are in the Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.,

    Stephen C Kales, Philip E Ryan & Stanley Lipkowitz

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  1. Stephen C Kales
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  2. Philip E Ryan
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  3. Stanley Lipkowitz
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Correspondence to Stanley Lipkowitz.

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The authors declare no competing financial interests.

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Kales, S., Ryan, P. & Lipkowitz, S. Cbl exposes its RING finger. Nat Struct Mol Biol 19, 131–133 (2012). https://doi.org/10.1038/nsmb.2241

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