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Germline transmission of RNAi in mice

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Figure 1: Heritable repression of Neil1 expression by RNAi in several tissues.
Figure 2: Reduction in Neil1 protein correlates with the presence of siRNAs.

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Acknowledgements

We thank S.Y. Kim for help with transgenesis experiments. M.A.C. is supported by a predoctoral fellowship from the U.S. Army Breast Cancer Research Program. G.J.H. is supported by an Innovator Award from the U.S. Army Breast Cancer Research Program and is a Rita Allen Foundation Scholar. This work was supported in part by grants from the N.I.H (G.J.H. and T.A.R). T.A.R. also thanks M. Frohman and A.P. Grollman for helpful discussions.

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Authors and Affiliations

  1. Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, 11724, New York, USA

    Michelle A. Carmell, Douglas S. Conklin & Gregory J. Hannon

  2. Program in Genetics, State University of New York at Stony Brook, Stony Brook, 11794, New York, USA

    Michelle A. Carmell

  3. University Transgenic Mouse Facility, State University of New York, Stony Brook, 11794, New York, USA

    Liqun Zhang & Thomas A. Rosenquist

  4. Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, 11794, New York, USA

    Thomas A. Rosenquist

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  1. Michelle A. Carmell
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  2. Liqun Zhang
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  4. Gregory J. Hannon
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Correspondence to Thomas A. Rosenquist.

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Carmell, M., Zhang, L., Conklin, D. et al. Germline transmission of RNAi in mice. Nat Struct Mol Biol 10, 91–92 (2003). https://doi.org/10.1038/nsb896

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