In response to DNA double-strand breaks, histone H1.2 translocates from the nucleus into the cytoplasm, leading to the mitochondrial release of cytochrome c and subsequent apoptosis of the cell. The molecular underpinnings for these processes remain enigmatic.
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References
Fernandez-Flores, A., Aguilera, B., Yau, P. & Oliva, H. Lancet 359, 1072 (2002).
Kerr, J.F.F., Wyllie, A.H. & Currie, A.R. Br. J. Cancer 26, 239–257 (1972).
Wang, X. Genes Dev. 15, 2922–2933 (2001).
Konishi, A. et al. Cell 114, 673–688 (2003).
Cory, S. & Adams, J.M. Nat. Rev. Cancer 2, 647–656 (2002).
Scorrano, L. & Korsmeyer, S.J. Biochem. Biophys. Res. Commun. 304, 437–444 (2003).
Shi, Y. Structure 10, 285–288 (2002).
Shi, Y. Mol. Cell 9, 459–470 (2002).
Thornberry, N.A. & Lazebnik, Y. Science 281, 1312–1316 (1998).
Li, P. et al. Cell 91, 479–489 (1997).
Du, C., Fang, M., Li, Y. & Wang, X. Cell 102, 33–42 (2000).
Verhagen, A.M. et al. Cell 102, 43–53 (2000).
Chai, J. et al. Nature 406, 855–862 (2000).
Li, W. et al. Nat. Struct. Biol. 9, 436–441 (2002).
Jones, J.M. et al. Nature 425, 721–727 (2003).
Wei, M.C. et al. Science 292, 727–730 (2001).
Puthalakath, H. & Strasser, A. Cell Death Differ. 9, 505–512 (2002).
Li, H. et al. Science 289, 1159–1164 (2000).
Marchenko, N.D., Zaika, A. & Moll, U.M. J. Biol. Chem. 275, 16202–16212 (2000).
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Yan, N., Shi, Y. Histone H1.2 as a trigger for apoptosis. Nat Struct Mol Biol 10, 983–985 (2003). https://doi.org/10.1038/nsb1203-983
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DOI: https://doi.org/10.1038/nsb1203-983
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