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A (ribo) switch in the paradigms of genetic regulation

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Proteins are the dogmatic workhorses of genetic regulation, able to both sense the presence of small molecules and control gene expression levels. Two recent studies have now shown that RNA molecules can also serve as the 'sensor' components of genetic regulatory circuits.

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Figure 1: Generalized scheme for feedback in genetic regulation.
Figure 2: Comparison of genetic control methods using RNA.

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Authors and Affiliations

  1. the Department of Chemistry and Biochemistry, Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, 78712, Texas, USA

    Jay R. Hesselberth & Andrew D. Ellington

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  1. Jay R. Hesselberth
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  2. Andrew D. Ellington
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Correspondence to Andrew D. Ellington.

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Hesselberth, J., Ellington, A. A (ribo) switch in the paradigms of genetic regulation. Nat Struct Mol Biol 9, 891–893 (2002). https://doi.org/10.1038/nsb1202-891

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