What prevents the replisome complex from moving along the DNA or breaking down when the replication fork stalls or encounters a DNA lesion? A recent paper describes how checkpoint proteins, Mrc1 and Tof1 couple the replisome to DNA synthesis.
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Zegerman, P., Diffley, J. Lessons in how to hold a fork. Nat Struct Mol Biol 10, 778–779 (2003). https://doi.org/10.1038/nsb1003-778
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DOI: https://doi.org/10.1038/nsb1003-778
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