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The CTD code

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How does the C-terminal domain (CTD) of RNA polymerase II interact specifically with multiple targets? A recent paper describing the structure of this domain with a mRNA capping enzyme guanylyltransferase suggests that the CTD is a contortionist that, upon post-translational modification, adopts different configurations specifically recognized by its partners.

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Figure 1: A possible CTD code.

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Authors and Affiliations

  1. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA

    Stephen Buratowski

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  1. Stephen Buratowski
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Buratowski, S. The CTD code. Nat Struct Mol Biol 10, 679–680 (2003). https://doi.org/10.1038/nsb0903-679

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