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Mini-proteins Trp the light fantastic

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A new 20-residue peptide represents the smallest example to date of cooperatively folded tertiary structure. This achievement provides a new tool for elucidating protein conformational preferences. The mini-protein should serve as a fruitful platform for protein design.

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Figure 1: Examples of mini-protein structures.

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Authors and Affiliations

  1. the Department of Chemistry University of Wisconsin, University of Wisconsin, Madison, 53706, Wisconsin, USA

    Samuel H. Gellman

  2. the Centre for Biomolecular Design & Drug Development, School of Biological Sciences, University of Sussex, Falmer, BN1 9QG, UK

    Derek N. Woolfson

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  1. Samuel H. Gellman
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  2. Derek N. Woolfson
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Gellman, S., Woolfson, D. Mini-proteins Trp the light fantastic. Nat Struct Mol Biol 9, 408–410 (2002). https://doi.org/10.1038/nsb0602-408

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