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Specific protein recognition of an mRNA cap through its alkylated base

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The specific binding of N7-methylguanine cap analogues to the RNA methyltransferase VP39 was observed through X-ray crystallography, providing a prototypical structure for a complex between a protein and an mRNA 5′ cap.

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Authors and Affiliations

  1. Howard Hughes Medical Institute and Department of Biochemistry, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, 77030, USA

    Alec E. Hodel & Florante A. Quiocho

  2. Department of Biochemistry and Biophysics, Institute of Biosciences and Technology, Texas A&M University, 2121 W. Holcombe Blvd., Houston, Texas, 77030, USA

    Paul D. Gershon, Xuenong Shi & Shi-Mei Wang

Authors
  1. Alec E. Hodel
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  2. Paul D. Gershon
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  3. Xuenong Shi
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  4. Shi-Mei Wang
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  5. Florante A. Quiocho
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Hodel, A., Gershon, P., Shi, X. et al. Specific protein recognition of an mRNA cap through its alkylated base. Nat Struct Mol Biol 4, 350–354 (1997). https://doi.org/10.1038/nsb0597-350

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  • DOI: https://doi.org/10.1038/nsb0597-350

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