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EDEM an ER quality control receptor

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Defective proteins in the endoplasmic reticulum (ER) are tagged as terminally aberrant by the composition of their N-linked glycans. The ER carbohydrate-binding protein EDEM selectively recognizes such tags and sorts the defective proteins for degradation via the ERAD pathway.

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Figure 1: ERAD recognition by the sequential binding of CNX and EDEM.
Figure 2: Proposed mechanism for EDEM binding.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, 01003, Massachusetts, USA

    Tao Wang & Daniel N. Hebert

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  1. Tao Wang
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  2. Daniel N. Hebert
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Correspondence to Daniel N. Hebert.

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Wang, T., Hebert, D. EDEM an ER quality control receptor. Nat Struct Mol Biol 10, 319–321 (2003). https://doi.org/10.1038/nsb0503-319

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