The monomeric B12-dependent ribonucleotide reductase from L. leichmannii has the central 10-stranded α/β-barrel found in all ribonucleotide reductases but incorporates two distinctive structural features, a novel cobalamin-binding fold and an insert forming part of a specificity control site that mimics the allosteric site found in the oligomeric di-iron dependent reductases.
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Ludwig, M., Matthews, R. Effector regulation in a monomeric enzyme. Nat Struct Mol Biol 9, 236–238 (2002). https://doi.org/10.1038/nsb0402-236
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DOI: https://doi.org/10.1038/nsb0402-236
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