Skip to main content
Log in

Induced flip

  • News & Views
  • Published:

From Nature Structural Biology

View current issue Submit your manuscript

Hhal methyltransferase, caught in the act of methylating a cytosine on a DNA substrate, reveals how the enzyme overcomes the problem of chemically modifying bases in the relatively inaccessible environment of the DNA duplex.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Klimasauskas, S., Kumar, S., Roberts, R.J. & Cheng, X. Cell (in the press).

  2. Adams, R.L.P. Biochem. J. 265, 309–320 (1990).

    Article  CAS  Google Scholar 

  3. Pósfai, J., Bhagwatt, A.S., Pósfai, G. & Roberts, R.J. Nucleic Acids Res., 17, 2421–2435 (1989).

    Article  Google Scholar 

  4. Wu, J.C. & Santi, D.V. in Biochemistry and biology of DNA methylation (eds G.I. Cantoni & A. Razin 119–129 Alan R. Liss New York 1985).

    Google Scholar 

  5. Roberts, R.J., Myers, P.A., Morrison, A & Murray, K.J. Molec. Biol. 103, 199–208 (1976).

    Article  CAS  Google Scholar 

  6. Mann, M.B. and Smith, H.O. In Proceedings of the conference on transmethylation (eds E Usdin, R. T., Borchardt & C.R. Creveling) 483–492 (Elsevier 1979).

    Google Scholar 

  7. Cheng, X., Kumar, S., Pösfai, J., Pflugrath, J.W. & Roberts, R.J. Cell, 74, 299–307 (1993).

    Article  CAS  Google Scholar 

  8. Osterman, D.G., Depillis, G.D., Wu, J.C., Matsuda, A & Santi, D.V. Biochemistry, 27, 5204–5210 (1988).

    Article  CAS  Google Scholar 

  9. Kim, Y., Geiger, J.H. & Sigler, P.B. Nature, 365, 512–520 (1993).

    Article  CAS  Google Scholar 

  10. Kim, J.L., Nikolov, D.B. & Burley, S.K. Nature, 365, 520–527 (1993).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Phillips, S. Induced flip. Nat Struct Mol Biol 1, 76–77 (1994). https://doi.org/10.1038/nsb0294-76

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsb0294-76

  • Springer Nature America, Inc.

Navigation