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Stones

The dark side of stone disease — stones do still kill

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A study investigating the mortality attributed to urolithiasis over a 15-year period has noted an increasing rate of death with a simultaneous rise in stone prevalence. However, the exact mechanisms by which nephrolithiasis causes death remains unclear.

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References

  1. Kum, F. et al. Do stones still kill? An analysis of death from stone disease 1999 to 2013 in England and Wales. BJU Int. http://dx.doi.org/10.1111/bju.13409 (2016).

  2. CDC/NCHS. Mortality by underlying and multiple cause, ages 18+: US, 1981–2013. knoema [online], (2015).

  3. Zisman, A. L., Evan, A. P., Coe, F. L. & Worcester, E. M. Do kidney stone formers have a kidney disease? Kidney Int. 88, 1240–1249 (2015).

    Article  Google Scholar 

  4. El-Zoghby, Z. M. et al. Urolithiasis and the risk of ESRD. Clin. J. Am. Soc. Nephrol. 7, 1409–1415 (2012).

    Article  Google Scholar 

  5. Lindell, A., Denneberg, T. & Granerus, G. Studies on renal function in patients with cystinuria. Nephron 77, 76–85 (1997).

    Article  CAS  Google Scholar 

  6. Edvardsson, V. O. et al. Hereditary causes of kidney stones and chronic kidney disease. Pediatr. Nephrol. 28, 1923–1942 (2013).

    Article  Google Scholar 

  7. Saran, R. et al. US renal data system 2014 annual data report: epidemiology of kidney disease in the United States. Am. J. Kidney Dis. 66, A7 (2015).

    Article  Google Scholar 

  8. Sakhaee, K. Epidemiology and clinical pathophysiology of uric acid kidney stones. J. Nephrol. 27, 241–245 (2014).

    Article  CAS  Google Scholar 

  9. Unsal, A. et al. Prediction of morbidity and mortality after percutaneous nephrolithotomy by using the Charlson Comorbidity Index. Urology 79, 55–60 (2012).

    Article  Google Scholar 

  10. Kreydin, E. I. & Eisner, B. H. Risk factors for sepsis after percutaneous renal stone surgery. Nat. Rev. Urol. 10, 598–605 (2013).

    Article  Google Scholar 

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Correspondence to Amy Krambeck.

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Rivera, M., Krambeck, A. The dark side of stone disease — stones do still kill. Nat Rev Urol 13, 247–248 (2016). https://doi.org/10.1038/nrurol.2016.56

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  • DOI: https://doi.org/10.1038/nrurol.2016.56

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