Brain white matter (axonal) abnormalities associated with interstitial cystitis/bladder pain syndrome in women suggest that neuropathological brain alterations exist in, and might contribute to, chronic pelvic pain syndromes. Advancing our knowledge of central neuropathic mechanisms, which might initiate and/or maintain these syndromes, will help target pain-related neuroplasticity and identify future treatments.
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References
Farmer, M. A. et al. Brain white matter abnormalities in female interstitial cystitis/bladder pain syndrome: A MAPP Network neuroimaging study. J. Urol. http://dx.doi.org/10.1016/j.juro.2015.02.082.
Finley, D. S. et al. Diffusion tensor magnetic resonance tractography of the prostate: feasibility for mapping periprostatic fibers. Urology 80, 219–223 (2012).
Farmer, M. A. et al. Brain functional and anatomical changes in chronic prostatitis/chronic pelvic pain syndrome. J. Urol. 186, 117–124 (2011).
Ceko, M. et al. Partial recovery of abnormal insula and dorsolateral prefrontal connectivity to cognitive networks in chronic low back pain after treatment. Hum. Brain Mapp. 36, 2075–2092 (2015).
Mansour, A. R. et al. Brain white matter structural properties predict transition to chronic pain. Pain 154, 2160–2168 (2013).
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Khavari, R., Boone, T. CNS changes in interstitial cystitis/painful bladder syndrome. Nat Rev Urol 12, 365–366 (2015). https://doi.org/10.1038/nrurol.2015.142
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DOI: https://doi.org/10.1038/nrurol.2015.142
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