Management of biochemically recurrent prostate cancer can be determined by the use of nomograms based on risk factors, but this approach might not lead to selection of optimal courses of treatment for individual patients. Choline-PET–CT imaging can identify the sites of recurrence in these patients, enabling personalized treatment choices depending on the presence of localized or metastatic disease.
References
Goldstein, J. et al. Does choline PET/CT change the management of prostate cancer patients with biochemical failure? Am. J. Clin. Oncol. http://dx.doi.org/10.1097/COC.0000000000000139.
Kattan, M. W., Wheeler, T. M. & Scardino, P. T. Postoperative nomogram for disease recurrence after radical prostatectomy for prostate cancer. J. Clin. Oncol. 17, 1499–1507 (1999).
Mohler, J. L. et al. Prostate cancer, version 1.2014. J. Natl Compr. Canc. Netw. 11, 1471–1479 (2013).
Heidenreich, A. et al. EAU guidelines on prostate cancer. Part II: Treatment of advanced, relapsing, and castration-resistant prostate cancer. Eur. Urol. 65, 467–479 (2014).
Berkovic, P. et al. Salvage stereotactic body radiotherapy for patients with limited prostate cancer metastases: deferring androgen deprivation therapy. Clin. Genitourin. Cancer 11, 27–32 (2013).
Suardi, N. et al. Long-term outcomes of salvage lymph node dissection for clinically recurrent prostate cancer: results of a single-institution series with a minimum follow-up of 5 years. Eur. Urol. http://dx.doi.org/10.1016/j.eururo.2014.02.011.
Castellucci, P. et al. Early biochemical relapse after radical prostatectomy: which prostate cancer patients may benefit from a restaging 11C-Choline PET/CT scan before salvage radiation therapy? J. Nucl. Med. 55, 1424–1429 (2014).
Soyka, J. D. et al. Clinical impact of 18F-choline PET/CT in patients with recurrent prostate cancer. Eur. J. Nucl. Med. Mol. Imaging 39, 936–943 (2012).
Ceci, F. et al. Impact of 11C-choline PET/CT on clinical decision making in recurrent prostate cancer: results from a retrospective two-centre trial. Eur. J. Nucl. Med. Mol. Imaging http://dx.doi.org/10.1007/s00259-014-2872-x.
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Castellucci, P., Fanti, S. Identifying sites of recurrence with choline-PET–CT imaging. Nat Rev Urol 12, 134–135 (2015). https://doi.org/10.1038/nrurol.2014.321
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DOI: https://doi.org/10.1038/nrurol.2014.321
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