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Osteoarthritis

In search of phenotypes

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Identifying different phenotypes of osteoarthritis is currently a subject of much research; however, a new systematic review has sparked discussion about the discrepancies in how research into disease phenotypes is conducted. Can we define individual phenotypes if we cannot agree on what constitutes a phenotype in the first place?

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Figure 1: Defining phenotypes of osteoarthritis based on dimensions of disease.

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Authors and Affiliations

  1. Department of General Practice and the Department of Orthopaedics, University Medical Centre Rotterdam Erasmus MC, PO Box 2040, Rotterdam, 3000, CA, Netherlands

    Sita M. Bierma-Zeinstra

  2. Department of General Practice, University Medical Centre Rotterdam Erasmus MC, PO Box 2040, Rotterdam, 3000, CA, Netherlands

    Marienke van Middelkoop

Authors
  1. Sita M. Bierma-Zeinstra
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  2. Marienke van Middelkoop
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Correspondence to Sita M. Bierma-Zeinstra.

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Competing interests

S.M.B-Z. declares that she has received consultancy fees from InFirst Healthcare and Regeneron. M.v.M. declares no competing interests.

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Bierma-Zeinstra, S., van Middelkoop, M. In search of phenotypes. Nat Rev Rheumatol 13, 705–706 (2017). https://doi.org/10.1038/nrrheum.2017.181

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