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When is familial Mediterranean fever 'severe'?

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Familial Mediterranean fever is a rare disorder but is usually easy to manage using colchicine. The publication of a severity score could serve as a useful reminder to rheumatologists about this disease and the difficulties in assessing its severity.

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References

  1. Tunca, M. et al. Familial Mediterranean fever (FMF) in Turkey: results of a nationwide multicenter study. Medicine (Baltimore) 84, 1–11 (2005).

    Article  Google Scholar 

  2. Ozen, S. et al. EULAR recommendations for the management of familial Mediterranean fever. Ann. Rheum. Dis. http://dx.doi.org/10.1136/annrheumdis-2015-208690, (2016).

  3. Demirkaya, E. et al. Development and initial validation of international severity scoring system for familial Mediterranean fever (ISSF). Ann. Rheum. Dis. http://dx.doi.org/10.1136/annrheumdis-2015-208671, (2016).

  4. Fujikura, K. Global epidemiology of familial Mediterranean fever mutations using population exome sequences. Mol. Genet. Genomic Med. 3, 272–282 (2015).

    Article  CAS  Google Scholar 

  5. Xu, H. et al. Innate immune sensing of bacterial modifications of rho GTPases by the pyrin inflammasome. Nature 513, 237–241 (2014).

    Article  CAS  Google Scholar 

  6. Akar, S. et al. Familial Mediterranean fever: risk factors, causes of death, and prognosis in the colchicine era. Medicine (Baltimore) 91, 131–136 (2012).

    Article  CAS  Google Scholar 

  7. Ben-Chetrit, E. & Levy, M. Colchicine: 1998 update. Semin. Arthritis Rheum. 28, 48–59 (1998).

    Article  CAS  Google Scholar 

  8. Eroglu, F. K., Besbas, N., Topaloglu, R. & Ozen, S. Treatment of colchicine-resistant familial Mediterranean fever in children and adolescents. Ann. Rheum. Dis. 35, 1733–1737 (2015).

    CAS  Google Scholar 

  9. Twig, G. et al. Mortality risk factors associated with familial Mediterranean fever among a cohort of 1.25 million adolescents. Ann. Rheum. Dis. 73, 704–709 (2014).

    Article  Google Scholar 

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Authors and Affiliations

  1. UCL Division of Medicine and Royal Free Hospital London NHS Foundation Trust, UK National Amyloidosis Centre, Rowland Hill Street, London, NW3 2PF, UK

    Helen J. Lachmann

  2. UCL Institute of Child Health and Great Ormond Street Hospital NHS Foundation Trust, 30 Guilford Street, London, WC1N 1EH, UK

    Paul A. Brogan

Authors
  1. Helen J. Lachmann
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  2. Paul A. Brogan
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Correspondence to Helen J. Lachmann.

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Lachmann, H., Brogan, P. When is familial Mediterranean fever 'severe'?. Nat Rev Rheumatol 12, 256–258 (2016). https://doi.org/10.1038/nrrheum.2016.55

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