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Regenerative medicine in 2016

Important milestones on the way to clinical translation

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From Nature Reviews Rheumatology

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Regenerative medicine can be viewed as 'tissue engineering V2.0'. Discoveries and novel applications of technology advanced the field considerably in 2016, with the use of new biomaterials, stem cells and biologically active molecules.

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Figure 1: Gene therapy combined with tissue engineering produces engineered constructs with therapeutic anticytokine effects.

References

  1. Rhee, S. et al. 3D bioprinting of spatially heterogeneous collagen constructs for cartilage tissue engineering. ACS Biomater. Sci. Eng. 2, 1800–1805 (2016).

    Article  CAS  Google Scholar 

  2. Lee, S. et al. On-demand three-dimensional freeform fabrication of multi-layered hydrogel with fluidic channels. Biotechnol. Bioeng. 105, 1178–1186 (2010).

    CAS  PubMed  Google Scholar 

  3. Ibusuki, S. et al. Photochemically cross-linked collagen gels as three-dimensional scaffolds for tissue engineering. Tissue Eng. 13, 1995–2001 (2007).

    Article  CAS  Google Scholar 

  4. Embree, M. C. et al. Exploiting endogenous fibrocartilage stem cells to regenerate cartilage and repair joint injury. Nat. Commun. 7, 13073 (2016).

    Article  CAS  Google Scholar 

  5. Dothwaite, G. P. et al. The surface of articular cartilage contains a progenitor cell population. J. Cell Sci. 117, 889–897 (2004).

    Article  Google Scholar 

  6. Lee, C. H. et al. Regeneration of the articular surface of the rabbit synovial joint by cell homing: a proof of concept study. Lancet 376, 440–448 (2010).

    Article  CAS  Google Scholar 

  7. Wehling, N. et al. Interleukin-1β and tumor necrosis factor α inhibit chondrogenesis by human mesenchymal stem cells through NF-κB dependent pathways. Arthritis Rheum. 60, 801–802 (2009).

    Article  CAS  Google Scholar 

  8. Heldens, G. T. et al. Catabolic factors and osteoarthritis-conditioned medium inhibit chondrogenesis of human mesenchymal stem cells. Tissue Eng. Part A 18, 45–54 (2012).

    Article  CAS  Google Scholar 

  9. Moutos, F. T. et al. Anatomically shaped tissue-engineered cartilage with tunable and inducible anticytokine delivery for biological joint resurfacing. Proc. Natl Acad. Sci. USA 113, E4513–E4522 (2016).

    Article  CAS  Google Scholar 

  10. Moutos, F. T., Freed, L. E. & Guilak, F. A biomimetic three-dimensional woven composite scaffold for functional tissue engineering of cartilage. Nat. Mater. 6, 162–167 (2007).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Daniel A. Grande is at the Department of Orthopedic Surgery and Orthopedic Research Laboratory, Feinstein Institute for Medical Research and North Shore-LIJ Health System, 350 Community Drive, Manhasset, New York 11030, USA.,

    Daniel A. Grande

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  1. Daniel A. Grande
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Correspondence to Daniel A. Grande.

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The author declares no competing financial interests.

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Grande, D. Important milestones on the way to clinical translation. Nat Rev Rheumatol 13, 67–68 (2017). https://doi.org/10.1038/nrrheum.2016.214

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