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Environment and genetics in gout: a maze for clinicians?

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The association of environmental dietary factors and polymorphisms of urate transporters with an increased risk of gout has been well established. Nevertheless, the influence of genetics and diet on serum urate concentrations, and the clinical relevance to individual patients, seems to be limited.

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Acknowledgements

This paper has been partially granted (9/13) by Asociación de Reumatologos del Hospital de Cruces.

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Authors and Affiliations

  1. Servicio de Reumatología and BioCruces Health Research Institute, Cruces University Hospital, Plaza Cruces S/N, Barakaldo, 48903, Spain

    Fernando Perez-Ruiz

  2. Physical Medicine Division, Hospital de Górliz, Astondo Ibitoki 2, Górliz, Spain

    Ana María Herrero-Beites

Authors
  1. Fernando Perez-Ruiz
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  2. Ana María Herrero-Beites
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Correspondence to Fernando Perez-Ruiz.

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Competing interests

F. Perez-Ruiz declares that he has acted as a consultant for AstraZeneca, Menarini, Novartis, Metabolex, Pfizer, and SOBI. A. M. Herrero-Beites declares no competing interests.

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Perez-Ruiz, F., Herrero-Beites, A. Environment and genetics in gout: a maze for clinicians?. Nat Rev Rheumatol 10, 8–9 (2014). https://doi.org/10.1038/nrrheum.2013.173

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