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Rheumatoid arthritis

Evidence for a genetic component to disease severity in RA

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Rheumatoid arthritis (RA) is partly heritable; genetic and serological markers are known to confer risk of developing pathology. But given clinical heterogeneity in RA, can we predict who will develop severe disease? Substantial heritability of erosive progression rates has now been identified, but better prognostic biomarkers remain wanting.

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Acknowledgements

The work of S. Raychaudhuri is supported by funds from the NIH (K08AR055688), Arthritis Foundation, the Harvard University Milton Fund, and Brigham and Women's Hospital. E. A. Stahl's work is supported by NIH grant U01GM092691 to Robert M. Plenge, MD PhD (Brigham and Women's Hospital, Harvard Medical School).

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Authors and Affiliations

  1. Divisions of Rheumatology and Genetics, Department of Medicine, Harvard Medical School, New Research Building (NRB), 77 Avenue Louis Pasteur, Suites 250/255, Boston, 02115, MA, USA

    Eli A. Stahl & Soumya Raychaudhuri

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  1. Eli A. Stahl
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  2. Soumya Raychaudhuri
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Correspondence to Soumya Raychaudhuri.

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Stahl, E., Raychaudhuri, S. Evidence for a genetic component to disease severity in RA. Nat Rev Rheumatol 8, 312–313 (2012). https://doi.org/10.1038/nrrheum.2012.74

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