Two randomized controlled trials have shown no significant differences in outcome between vertebroplasty and a sham procedure in patients with back pain and vertebral fracture. What conclusions can be drawn from these results?
References
Buchbinder, R. et al. A randomized trial of vertebroplasty for painful osteoporotic vertebral fractures. N. Engl. J. Med. 361, 557–568 (2009).
Kallmes, D. F. et al. A randomized trial of vertebroplasty for osteoporotic spinal fractures. N. Engl. J. Med. 361, 569–579 (2009).
Weinstein, J. N. Balancing science and informed choice in decisions about vertebroplasty. N. Engl. J. Med. 361, 619–621 (2009).
Rousing, R., Andersen, M. O., Jespersen, S. M., Thomsem, K. & Lauritsen, J. Percutaneous vertebroplasty compared to conservative treatment in patients with painful acute or subacute vertebral compression fractures: three month follow-up in a clinical randomized study. Spine 34, 1349–1354 (2009).
Diamond, T. H., Champion, D. B. & Clark, W. A. Management of acute osteoporotic vertebral compression fractures: a nonrandomized trial comparing percutaneous vertebroplasty with conservative therapy. Am. J. Med. 114, 257–265 (2003).
Alvarez, L. et al. Percutaneous vertebroplasty. Functional improvements in patients with osteoporotic compression fractures. Spine 31, 1113–1118 (2006).
Wardlaw, D. et al. Efficacy and safety of balloon kyphoplasty compared with non-surgical care for vertebral compression fracture (FREE): a randomised controlled trial. Lancet 373, 1016–1024 (2009).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
Dr. Andersson is a stockholder/director of Crosstrees Medical, Inc.
Rights and permissions
About this article
Cite this article
Andersson, G. Vertebroplasty: one solution does not fit all. Nat Rev Rheumatol 5, 662–663 (2009). https://doi.org/10.1038/nrrheum.2009.233
Issue Date:
DOI: https://doi.org/10.1038/nrrheum.2009.233
- Springer Nature Limited