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Alzheimer disease

CSF biomarkers for Alzheimer disease — approaching consensus

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A European working group has provided a new set of recommendations for the use of cerebrospinal fluid (CSF) biomarkers in the diagnostic evaluation of Alzheimer disease and mild cognitive impairment. These recommendations represent an important step towards the implementation of CSF biomarker tests in the clinic, but several challenges remain.

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References

  1. McKhann, G. M. et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging–Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 7, 263–269 (2011).

    Article  Google Scholar 

  2. Dubois, B. et al. Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria. Lancet Neurol. 11, 614–629 (2014).

    Article  Google Scholar 

  3. Simonsen, A. H. et al. Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia. Alzheimers Dement. http://dx.doi.org/10.1016/j.jalz.2016.09.008 (2016).

  4. Herukka, S.-K. et al. Recommendations for CSF AD biomarkers in the diagnostic evaluation of MCI. Alzheimers Dement. http://dx.doi.org/10.1016/j.jalz.2016.09.009 (2016).

  5. Carrillo, M. C. et al. Global standardization measurement of cerebral spinal fluid for Alzheimer's disease: an update from the Alzheimer's Association Global Biomarkers Consortium. Alzheimers Dement. 9, 137–140 (2013).

    Article  Google Scholar 

  6. Bittner, T. et al. Technical performance of a novel fully automated electrochemiluminescence immunoassay for the quantitation of β-amyloid (1–42) in human cerebrospinal fluid. Alzheimers Dement. 12, 517–526 (2016).

    Article  Google Scholar 

  7. Panee, J. et al. Round robin test on qualification of amyloid-B 1–42 in cerebrospinal fluid by mass spectrometry. Alzheimers Dement. 12, 55–59 (2016).

    Article  Google Scholar 

  8. Struyfs, H. et al. Diagnostic accuracy of cerebrospinal fluid amyloid-β Isoforms for early and differential dementia diagnosis. J. Alzheimers Dis. 45, 813–822 (2015).

    Article  CAS  Google Scholar 

  9. Palmqvist, S. et al. Detailed comparison of amyloid PET and CSF biomarkers for identifying early Alzheimer disease. Neurology 85, 1240–1249 (2015).

    Article  CAS  Google Scholar 

  10. Jack, C. R. et al. A/T/N: an unbiased descriptive classification scheme for Alzheimer disease biomarkers. Neurology 87, 539–547 (2016).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors acknowledge grant support from the NIH National Institute on Aging (grant AGO5131 to D.R.G. and grant U01 AG024904 to L.M.S.).

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Correspondence to Leslie M. Shaw.

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Galasko, D., Shaw, L. CSF biomarkers for Alzheimer disease — approaching consensus. Nat Rev Neurol 13, 131–132 (2017). https://doi.org/10.1038/nrneurol.2017.11

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