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Decade in review—epilepsy

Edging toward breakthroughs in epilepsy diagnostics and care

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The past decade has yielded a host of important conceptual advances in epilepsy, along with some promising findings related to diagnostics and therapeutics. We are on an upswing where precise identification of the cause of a patient's seizure disorder can be matched to therapy that has a high likelihood of success.

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References

  1. Fisher, R. S. et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia 55, 475–482 (2014).

    Article  Google Scholar 

  2. Jensen, F. E. Epilepsy as a spectrum disorder: implications from novel clinical and basic neuroscience. Epilepsia 52, 1–6 (2011).

    Article  Google Scholar 

  3. Truccolo, W. et al. Single-neuron dynamics in human focal epilepsy. Nat. Neurosci. 14, 635–641 (2011).

    Article  CAS  Google Scholar 

  4. Epi4K Consortium & Epilepsy Phenome/Genome Project. De novo mutations in epileptic encephalopathies. Nature 501, 217–221 (2013).

  5. Helbig, I. et al. 15q13.3 microdeletions increase risk of idiopathic generalized epilepsy. Nat. Genet. 41, 160–162 (2009).

    Article  CAS  Google Scholar 

  6. International League Against Epilepsy Consortium on Complex Epilepsies. Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies. Lancet Neurol. 13, 893–903 (2014).

  7. Seeck, M., Zacharia, A. & Rossetti, A. O. Autoimmune epilepsy [French]. Rev. Med. Suisse 6, 925–929 (2010).

    CAS  PubMed  Google Scholar 

  8. Paz, J. T. et al. Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury. Nat. Neurosci. 16, 64–70 (2013).

    Article  CAS  Google Scholar 

  9. Hunt, R. F., Girskis, K. M., Rubenstein, J. L., Alvarez-Buylla, A. & Baraban, S. C. GABA progenitors grafted into the adult epileptic brain control seizures and abnormal behaviour. Nat. Neurosci. 16, 692–697 (2013).

    Article  CAS  Google Scholar 

  10. EpiPM Consortium. A road map for precision medicine in the epilepsies. Lancet Neurol. http://dx.doi.org/10.1016/S1474-4422(15)00199-4.

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Acknowledgements

D.H.L. has received research grants from the NIH (U01NS077274 and U01NS077276).

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Correspondence to Daniel H. Lowenstein.

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Lowenstein, D. Edging toward breakthroughs in epilepsy diagnostics and care. Nat Rev Neurol 11, 616–617 (2015). https://doi.org/10.1038/nrneurol.2015.193

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