A surprisingly high rate of nonconvulsive seizures and status epilepticus is found during continuous EEG monitoring in critically ill patients. A recent analysis of data regarding hospitalization and mortality in patients with status epilepticus emphasizes the relevance not only of how status epilepticus is defined, but also of how it is detected.
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References
Betjemann, J. P., Josephson, S. A., Lowenstein, D. H. & Burke, J. F. Trends in status epilepticus-related hospitalizations and mortality: redefined in us practice over time. JAMA Neurol. 72, 650–655 (2015).
Dham, B. S., Hunter, K. & Rincon, F. The epidemiology of status epilepticus in the United States. Neurocrit. Care 20, 476–483 (2014).
Silbergleit, R. et al. RAMPART (Rapid Anticonvulsant Medication Prior to Arrival Trial): a double-blind randomized clinical trial of the efficacy of intramuscular midazolam versus intravenous lorazepam in the prehospital treatment of status epilepticus by paramedics. Epilepsia 52 (Suppl. 8), 45–47 (2011).
Herman, S. T. et al. Consensus statement on continuous EEG in critically ill adults and children, part I: indications. J. Clin. Neurophysiol. 32, 87–95 (2015).
Gilmore, E. J. et al. Acute brain failure in severe sepsis: a prospective study in the medical intensive care unit utilizing continuous EEG monitoring. Intensive Care Med. 41, 686–694 (2015).
Kamel, H. et al. Diagnostic yield of electroencephalography in the medical and surgical intensive care unit. Neurocrit. Care 19, 336–341 (2013).
Brophy, G. M. et al. Guidelines for the evaluation and management of status epilepticus. Neurocrit. Care 17, 3–23 (2012).
Hirsch, L. J. et al. American Clinical Neurophysiology Society's standardized critical care EEG terminology: 2012 version. J. Clin. Neurophysiol. 30, 1–27 (2013).
Hirsch, L. J. & Gaspard, N. Status epilepticus. Continuum (Minneap. Minn.) 19, 767–794 (2013).
Payne, E. T. et al. Seizure burden is independently associated with short term outcome in critically ill children. Brain 137, 1429–1438 (2014).
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L.J.H. receives royalties for Hirsch, L. J. & Brenner, R. P. (Eds) Atlas of EEG in Critical Care (Wiley, 2010). He also spends about 25% of his billable time implementing and interpreting continuous EEG monitoring. E.J.G. declares no competing interests.
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Gilmore, E., Hirsch, L. Status epilepticus epidemiology—tracking a moving target. Nat Rev Neurol 11, 377–378 (2015). https://doi.org/10.1038/nrneurol.2015.104
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DOI: https://doi.org/10.1038/nrneurol.2015.104
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