At least 10% of diagnoses of Parkinson disease that are made while the patient is alive are not confirmed at autopsy. To help address this issue, the European Federation of Neurology and the Movement Disorder Society European Section have provided evidence-based guidelines and recommendations for clinical diagnosis of Parkinson disease.
References
Hughes, A. J., Daniel, S. E., Ben-Shlomo, Y. & Lees, A. J. The accuracy of diagnosis of parkinsonian syndromes in a specialized movement disorder service. Brain 125, 861–870 (2002).
Schrag, A., Ben-Shlomo, Y. & Quinn, N. How valid is the clinical diagnosis of Parkinson's disease in the community? J. Neurol. Neurosurg. Psychiatry 73, 529–534 (2002).
Berardelli A. et al. EFNS/MDS-ES recommendations for the diagnosis of Parkinson's disease. Eur. J. Neurol. 20, 16–34 (2013).
Brainin, M. et al. Guidance for the preparation of neurological management guidelines by EFNS scientific task forces—revised recommendation 2004. Eur. J. Neurol. 11, 577–581 (2004).
Lees, A. J., Hardy, J. & Revesz, T. Parkinson's disease. Lancet 373, 2055–2066 (2009).
National Collaborating Centre for Chronic Conditions. Parkinson's Disease: National Clinical Guideline for Management in Primary and Secondary Care (Royal College of Physicians, London, 2006).
Tolosa, E. & Pont-Sunyer, C. Progress in defining the premotor phase of Parkinson's disease. J. Neurol. Sci. 310, 4–8 (2011).
Leone, M. A. et al. Guidance for the preparation of neurological management guidelines by EFNS scientific task forces—revised recommendations 2012. Eur. J. Neurol. 20, 410–419 (2013).
Wu, Y., Weidong, L. & Jankovic, J. Preclinical biomarkers of Parkinson disease. Arch. Neurol. 68, 22–30 (2011).
Acknowledgements
E. Tolosa is the Principal Investigator of Grant PI041639 from The Michael J. Fox Foundation for Parkinson Disease.
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E. Tolosa has been a consultant to Boehringer Ingelheim, Novartis, UCB, GSK, Teva and Lundbeck. He has received honoraria for speaking from Boehringer Ingelheim, Novartis, UCB, Solvay, Teva and Lundbeck. M. J. Martí declares no competing interests.
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Martí, M., Tolosa, E. New guidelines for diagnosis of Parkinson disease. Nat Rev Neurol 9, 190–191 (2013). https://doi.org/10.1038/nrneurol.2013.47
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DOI: https://doi.org/10.1038/nrneurol.2013.47
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