In 2012, studies of autosomal dominant Alzheimer disease (AD), late-onset AD, and a rare genetic mutation of amyloid precursor protein provided support for the critical role of amyloid in AD pathogenesis. Increasing evidence implicated cell-to-cell transmission in the spread of tau and amyloid, highlighting novel targets for therapeutic intervention.
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M. W. Weiner is a stockholder/director of Elan.
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Weiner, M. Further insights into Alzheimer disease pathogenesis. Nat Rev Neurol 9, 65–66 (2013). https://doi.org/10.1038/nrneurol.2012.275
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DOI: https://doi.org/10.1038/nrneurol.2012.275
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