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Alzheimer disease

New light on an old CLU

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A Correction to this article was published on 01 February 2010

Genome-wide association studies (GWAS) have uncovered over two dozen candidate Alzheimer disease susceptibility genes; however, the results of these studies showed limited overlap. Two independently performed GWAS involving cohorts from Europe and the US have now identified three additional putative Alzheimer disease genes that show modest but remarkably consistent effects across data sets.

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References

  1. Bertram, L. & Tanzi, R. E. Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses. Nat. Rev. Neurosci. 9, 768–778 (2008).

    Article  CAS  Google Scholar 

  2. Lambert, J. C. et al. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat. Genet. 41, 1094–1099 (2009).

    Article  CAS  Google Scholar 

  3. Harold, D. et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat. Genet. 41, 1088–1093 (2009).

    Article  CAS  Google Scholar 

  4. Bertram, L., McQueen, M., Mullin, K., Blacker, D. & Tanzi, R. The AlzGene Database. Alzheimer Research Forum [online], (2009).

    Google Scholar 

  5. Reiman, E. M. et al. GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers. Neuron 54, 713–720 (2007).

    Article  CAS  Google Scholar 

  6. Li, H. et al. Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease. Arch. Neurol. 65, 45–53 (2008).

    Article  Google Scholar 

  7. Bertram, L. et al. Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. Am. J. Hum. Genet. 83, 623–632 (2008).

    Article  CAS  Google Scholar 

  8. Zlokovic, B. V. Cerebrovascular transport of Alzheimer's amyloid beta and apolipoproteins J and E: possible anti-amyloidogenic role of the blood–brain barrier. Life Sci. 59, 1483–1497 (1996).

    Article  CAS  Google Scholar 

  9. Wyss-Coray, T. et al. Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice. Proc. Natl Acad. Sci. USA 99, 10837–10842 (2002).

    Article  CAS  Google Scholar 

  10. Harel, A., Wu, F., Mattson, M. P., Morris, C. M. & Yao, P. J. Evidence for CALM in directing VAMP2 trafficking. Traffic 9, 417–429 (2008).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Neuropsychiatric Genetics Group, Max-Planck Institute for Molecular Genetics, Ihnestrasse 63, Room 204.1, Berlin, 14195, Germany

    Lars Bertram

  2. Department of Neurology, Genetics and Aging Research Unit, Massachusetts General Hospital, 114 16th Street, Charlestown, 02129, MA, USA

    Rudolph E. Tanzi

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  1. Lars Bertram
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  2. Rudolph E. Tanzi
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Correspondence to Lars Bertram.

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The authors declare no competing financial interests.

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Bertram, L., Tanzi, R. New light on an old CLU. Nat Rev Neurol 6, 11–13 (2010). https://doi.org/10.1038/nrneurol.2009.213

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