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Angiomyolipoma

A link between stemness and tumorigenesis in the kidney

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From Nature Reviews Nephrology

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The cellular origins of angiomyolipoma and other tuberous sclerosis complex-associated neoplasms are unknown. Now, two studies show that these neoplasms derive from cancer stem cells that originate from multipotent renal epithelial cells. The new findings provide a link between stemness and tumorigenesis in the kidney.

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Figure 1: Models of kidney regeneration and angiomyolipoma tumorigenesis.

References

  1. Henske, E. P. et al. Tuberous sclerosis complex. Nat. Rev. Dis. Primers. 2, 16035 (2016).

    Article  Google Scholar 

  2. Fittschen, A. et al. Prevalence of sporadic renal angiomyolipoma: a retrospective analysis of 61,389 in- and out-patients. Abdom. Imag. 39, 1009–1013 (2014).

    Article  Google Scholar 

  3. Paradis, V. et al. Clonal analysis of renal sporadic angiomyolipomas. Hum. Pathol. 29, 1063–1067 (1998).

    Article  CAS  Google Scholar 

  4. Goncalves, A. F. et al. Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells. Nat. Commun. 8, 1466 /10.1038/s41467-017-01514-3(2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Cho, J. H. et al. Notch transactivates Rheb to maintain the multipotency of TSC-null cells. Nat. Commun. 8, 184 /10.1038/s41467-017-01845-1(2017).

    Article  CAS  Google Scholar 

  6. Romagnani, P., Lasagni, L. & Remuzzi, G. Renal progenitors: an evolutionary conserved strategy for kidney regeneration. Nat. Rev. Nephrol. 9, 137–146 (2013).

    Article  CAS  Google Scholar 

  7. Sagrinati, C. et al. Isolation and characterization of multipotent progenitor cells from the Bowman's capsule of adult human kidneys. J. Am. Soc. Nephrol. 17, 2443–2456 (2006).

    Article  CAS  Google Scholar 

  8. Rinkevich, Y. et al. In vivo clonal analysis reveals lineage-restricted progenitor characteristics in mammalian kidney development, maintenance, and regeneration. Cell Rep. 7, 1270–1283 (2014).

    Article  CAS  Google Scholar 

  9. Batlle, E. & Clevers, H. Cancer stem cells revisited. Nat. Med. 23, 1124–1134 (2017).

    Article  CAS  Google Scholar 

  10. Lazzeri, E. et al. Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury. Nat. Commun. (in the press).

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Acknowledgements

P.R. is supported by the European Research Council under the Consolidator Grant RENOIR (ERC-2014-CoG), grant number 648274.

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Authors and Affiliations

  1. Department of Biomedical Experimental and Clinical Sciences “Mario Serio”, the Excellence Centre for Research, Transfer and High Education DENOTHE, University of Florence, Florence, Italy

    Francesca Becherucci & Paola Romagnani

  2. Pediatric Nephrology Unit, Meyer Children's Hospital, Florence, Italy

    Francesca Becherucci & Paola Romagnani

Authors
  1. Francesca Becherucci
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  2. Paola Romagnani
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Correspondence to Paola Romagnani.

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The authors declare no competing financial interests.

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Becherucci, F., Romagnani, P. A link between stemness and tumorigenesis in the kidney. Nat Rev Nephrol 14, 215–216 (2018). https://doi.org/10.1038/nrneph.2018.16

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