Skip to main content

Advertisement

Log in

Epidemiology

The global burden of reduced GFR: ESRD, CVD and mortality

  • News & Views
  • Published:

From Nature Reviews Nephrology

View current issue Sign up to alerts

New data highlight the increasing global burden of cardiovascular disease, end-stage renal disease and disability adjusted life years that can be attributed to reduced glomerular filtration rate (GFR). These findings underline the need to evaluate whether screening for chronic kidney disease is effective and if early interventions can reduce the incidence of GFR-attributable adverse events.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Mills, K. T. et al. A systematic analysis of worldwide population-based data on the global burden of chronic kidney disease in 2010. Kidney Int. 88, 950–957 (2015).

    Article  Google Scholar 

  2. GBD 2015 DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 388, 1603–1658 (2016).

  3. Ene-Iordache, B. et al. Chronic kidney disease and cardiovascular risk in six regions of the world (ISN-KDDC): a cross-sectional study. Lancet Glob. Health 4, e307–e319 (2016).

    Article  Google Scholar 

  4. O'Hare, A. M. et al. Age affects outcomes in chronic kidney disease. J. Am. Soc. Nephrol. 18, 2758–2765 (2007).

    Article  Google Scholar 

  5. Thomas, B. et al. Global cardiovascular and renal outcomes of reduced GFR. J. Am. Soc. Nephrol. http://dx.doi.org/10.1681/ASN.2016050562 (2017).

  6. GBD 2013 Risk Factors Collaborators et al. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 386, 2287–2323 (2015).

  7. Schmieder, R. E. et al. Changes in albuminuria predict mortality and morbidity in patients with vascular disease. J. Am. Soc. Nephrol. 22, 1353–1364 (2011).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mark J. Sarnak.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sharma, S., Sarnak, M. The global burden of reduced GFR: ESRD, CVD and mortality. Nat Rev Nephrol 13, 447–448 (2017). https://doi.org/10.1038/nrneph.2017.84

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneph.2017.84

  • Springer Nature Limited

This article is cited by

Navigation