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Chronic kidney disease

KDIGO CKD–MBD guideline update: evolution in the face of uncertainty

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Management of mineral and bone disorders in patients with chronic kidney disease (CKD–MBD) requires an understanding of the complex interactions among ions, hormones and their target organs. Since publication of the KDIGO CKD–MBD guideline in 2009, our understanding of disease pathophysiology has improved; however, a paucity of high-quality clinical evidence to support specific interventions remains. Using available data, KDIGO has now updated diagnostic and therapeutic recommendations for patients with CKD–MBD.

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Figure 1: Revised recommendations from the 2017 KDIGO CKD–MBD guideline.

References

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Acknowledgements

W.C. is supported in part by the American Society of Nephrology Carl W. Gottschalk Research Grant. D.A.B. is supported in part by a NIH grant (2R01DK075462). Both researchers receive grant support from the Renal Research Institute.

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Authors and Affiliations

  1. Department of Medicine, University of Rochester School of Medicine and Dentistry,

    Wei Chen

  2. Department of Medicine and Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, BOX 675, Rochester, 14642, New York, USA

    David A. Bushinsky

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  1. Wei Chen
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  2. David A. Bushinsky
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Correspondence to David A. Bushinsky.

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Competing interests

D.A.B. is a consultant for Relyspa, Amgen, Sanofi/Genzyme, Vifor, and Tricida and has an equity interest in Amgen and Tricida. W.C. declares no competing interests.

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Chen, W., Bushinsky, D. KDIGO CKD–MBD guideline update: evolution in the face of uncertainty. Nat Rev Nephrol 13, 600–602 (2017). https://doi.org/10.1038/nrneph.2017.118

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