The heterogeneity of pathomechanisms leading to systemic lupus erythematosus (SLE) might contribute to between-patient variations in treatment response. A new, longitudinal transcriptome analysis has identified molecularly distinct subgroups of SLE that correlate with disease activity; use of such disease classifiers might facilitate the development of stratified treatment recommendations.
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Acknowledgements
Critical review of the manuscript by Heather K. Ascani, University of Michigan, before submission, is greatly appreciated. H.-J.A. is supported by the European Union's Horizon 2020 research and innovation program under grant agreement No. 668036 (RELENT). M.K. is supported by NIH U54 DK083912, Nephrotic Syndrome Rare Disease Clinical Research Network II, and NIH P30 DK081943 George M. O'Brien Kidney Research Core Center at the University of Michigan.
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Anders, HJ., Kretzler, M. Personalized immunomonitoring in lupus and lupus nephritis. Nat Rev Nephrol 12, 320–321 (2016). https://doi.org/10.1038/nrneph.2016.69
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DOI: https://doi.org/10.1038/nrneph.2016.69
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