Skip to main content

Advertisement

SpringerLink
Log in

Imaging

BOLD assessment—effects of RAAS inhibition in CKD

  • News & Views
  • Published:

From Nature Reviews Nephrology

View current issue Sign up to alerts

Blood-oxygen-level-dependent MRI enables noninvasive assessment of renal deoxyhaemoglobin levels and, therefore, hypoxia. As decreased tissue oxygenation might contribute to acute and chronic kidney disease (CKD), this tool has been examined in patients with CKD. Indeed, the benefits of renin–angiotensin–aldosterone system inhibitors might be partly conferred by increased oxygenation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Gloviczki, M. L. et al. Blood oxygen level-dependent magnetic resonance imaging identifies cortical hypoxia in severe renovascular disease. Hypertension 58, 1066–1072 (2011).

    Article  CAS  Google Scholar 

  2. Siddiqi, L. et al. Inhibition of the renin–angiotensin system affects kidney tissue oxygenation evaluated by magnetic resonance imaging in patients with chronic kidney disease. J. Clin. Hypertens. 16, 214–218 (2014).

    Article  CAS  Google Scholar 

  3. Manotham, K. et al. Angiotensin II receptor blocker partially ameliorated intrarenal hypoxia in chronic kidney disease patients: a pre-/post-study. Intern. Med. J. 42, e33–e37 (2012).

    Article  CAS  Google Scholar 

  4. Welch, W. J., Mendonca, M., Aslam, S. & Wilcox, C. S. Roles of oxidative stress and AT1 receptors in renal hemodynamics and oxygenation in the postclipped 2K,1C kidney. Hypertension 41, 692–696 (2003).

    Article  CAS  Google Scholar 

  5. Palm, F., Onozato, M., Welch, W. J. & Wilcox, C. S. Blood pressure, blood flow, and oxygenation in the clipped kidney of chronic 2-kidney, 1-clip rats: effects of tempol and angiotensin blockade. Hypertension 55, 298–304 (2010).

    Article  CAS  Google Scholar 

  6. Inoue, T. et al. Noninvasive evaluation of kidney hypoxia and fibrosis using magnetic resonance imaging. J. Am. Soc. Nephrol. 22, 1429–1434 (2011).

    Article  Google Scholar 

  7. Gloviczki, M. L. et al. Comparison of 1.5 and 3 T BOLD MR to study oxygenation of kidney cortex and medulla in human renovascular disease. Invest. Radiol. 44, 566–571 (2009).

    Article  CAS  Google Scholar 

  8. Michaely, H. J. et al. Renal BOLD–MRI does not reflect renal function in chronic kidney disease. Kidney Int. 81, 684–689 (2012).

    Article  CAS  Google Scholar 

  9. Pruijm, M. et al. Blockade of the renin-angiotensin system and renal tissue oxygenation as measured with BOLD–MRI in patients with type 2 diabetes. Diabetes Res. Clin. Pract. 99, 136–144 (2013).

    Article  CAS  Google Scholar 

  10. Textor, S. C. et al. The use of magnetic resonance to evaluate tissue oxygenation in renal artery stenosis. J. Am. Soc. Nephrol. 19, 780–788 (2008).

    Article  Google Scholar 

Download references

Acknowledgements

The author is partly supported by NIH grants DK73608, DK100081, HL77131 and HL121561.

Author information

Authors and Affiliations

  1. Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, 55905, MN, USA

    Lilach O. Lerman

Authors
  1. Lilach O. Lerman
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Lilach O. Lerman.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lerman, L. BOLD assessment—effects of RAAS inhibition in CKD. Nat Rev Nephrol 10, 247–248 (2014). https://doi.org/10.1038/nrneph.2014.58

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneph.2014.58

  • Springer Nature Limited

Search

Navigation